Genome-wide association study of Alzheimer's disease with psychotic symptoms

P Hollingworth, R Sweet, R Sims, D Harold… - Molecular …, 2012 - nature.com
… a disease subtype … genome-wide association studies (GWASs) to identify loci that (1) increase
susceptibility to an AD and subsequent psychotic symptoms; or (2) modify risk of psychotic

Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

, … Based Study Consortium, Alzheimer's Disease … - Molecular …, 2021 - nature.com
… We now report a large genome-wide association meta-analysis of 12,317 AD subjects with
and without psychosis. We identified two loci with genome-wide significant associations with …

An overview of genome-wide association studies in Alzheimer's disease

L Shen, J Jia - Neuroscience bulletin, 2016 - Springer
Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility
genes for Alzheimer’s disease (… AD patients with psychotic symptoms are associated with …

Psychosis in Alzheimer's disease

PS Murray, S Kumar, MAA DeMichele-Sweet… - Biological …, 2014 - Elsevier
genome-wide association study of AD + P has generated some promising leads. The study
… syndromes and cognitive domains in Alzheimer disease: The impact of mood and psychosis

Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease

, … consortium and the Alzheimer's Disease … - Translational …, 2019 - nature.com
… Linkage studies have also implicated regions of the … study which, surprisingly, reported that
a genetic risk score comprising 94 SNPs reaching genome-wide significance for association

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

C Gouveia, E Gibbons, N Dehghani, J Eapen… - Scientific Reports, 2022 - nature.com
genome-wide association studies (GWAS) have greatly improved the statistical power to detect
novel genetic associations … can be observed with psychiatric traits such as schizophrenia, …

Multi-trait analysis for genome-wide association study of five psychiatric disorders

Y Wu, H Cao, A Baranova, H Huang, S Li, L Cai… - Translational …, 2020 - nature.com
… We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia
(SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n …

Genetics of psychosis of Alzheimer disease

C Shah, MAA DeMichele‐Sweet… - American Journal of …, 2017 - Wiley Online Library
… Other candidate gene studies focusing on monoamine … A genome-wide association study
and studies examining copy number variations recently have detected suggestive associations

Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data

J Gibson, TC Russ, MJ Adams, TK Clarke… - Translational …, 2017 - nature.com
… score regression with genome-wide association study (GWAS… of Alzheimer's Project (IGAP)
and the Psychiatric Genomics … with Alzheimer's disease. Nat Genet 2009; 41: 1094–1099. …

A genome-wide association study of a sustained pattern of antidepressant response

AM Hunter, AF Leuchter, RA Power, B Muthén… - … of psychiatric research, 2013 - Elsevier
Genome-wide association studies (GWAS) have failed to replicate common genetic variants
associated with antidepressant response, as defined using a single endpoint. Genetic …